Oridzin – Uses, Benefits, Sources, Side Effects, & Precautions

Oridzin does not exist at all! Our SEO professional found this term during the keyword research procedure. But the actual term is Phloridzin—it’s a phytochemical, first extracted from the bark of apple trees. Keep reading to learn more in detail about Oridzin, i.e., Phloridzin!

People these days are more concerned about their health than ever. And researchers in the field are digging through the woods to cure various conditions. In the same run for natural and beneficial plant extracts, scientists today have found one of the best extracts called Phloridzin. 

On the internet, you’ll see results about Oridzin and its benefits, but don’t believe in this. In this article, I’ll explore the actual uses, benefits, sources, side effects, and precautions of Oridzin. By reading this article, you’ll learn what actually Orid-zin is and the science behind it.

Oridzin – A Quick Overview

A quote about Apples, “An apple a day keeps the doctor away,” fits perfectly here as this fruit has done wonders. After studies have found its health-promoting effects, it has become the most commonly consumed fruit worldwide. And Oridzin (Phloridzin) is one reason behind it. 

Orid-zin, one of the best extracts, is best for people with diabetes, cardiovascular problems, and cancer. It’s a flavonoid glycoside, a naturally occurring compound that has antioxidant effects. By consuming such foods, the quality of human life can be increased without taking medicine.

History & Origin of Oridzin

The history of Orid-zin dates back to 1835 when a breakthrough in research unfolded. It was De Koninck, a French scientist, who isolated Phloridzin from the bark of apple trees. Initially, this compound cured fever and malaria. But later on, its other beneficial effects were uncovered.

Phloridzin belongs to the chalcone class of organic compounds and is present in plants of the Malus genus, especially apples. Initially identified to degrade lactose, its significance expanded to inhibit renal glucose absorption, causing glucosuria. The journey doesn’t stop there!

Health Benefits of Oridzin

In medicine, especially related to plant extracts, researchers are always going on to find the benefits of compounds for humans. Oridzin is one of them, and in this section, I’ll discuss how it affects your overall health. Here’s why Phloridzin has captured the attraction of researchers:

The Cure For Diabetes Mellitus 

Oridzin has antihyperglycemic effects by influencing glucose metabolism. Studies show that it can modulate glucose absorption in the intestines and regulate renal glucose reabsorption. This compound can normalize blood glucose levels, preventing proteinuria and kidney-related issues. 

This compound has some limitations, such as poor absorption and low bioavailability. However, it has paved the way for the development of antidiabetic drugs. After this, some drugs have been manufactured and successfully used in developed countries for the treatment of diabetes.  

Fight Aging, Improves Skin Health 

Orid-zin acts as an antioxidant; neutralizes free radicals, inhibits lipid peroxidation, and enhances antioxidant enzyme activity. Its presence in various plant sources, including apples, contributes to the antioxidant properties of these plants. So, it can fight aging and keep you young.

These effects go beyond mere free radical neutralization. Oridzin impacts lipid peroxidation and exhibits protective qualities against oxidative stress-induced damage. Research indicates that its antioxidant activity plays a role in maintaining skin elasticity and integrity. 

A Good Agent To Fight Infections

In several laboratory studies, Orid-zin has exhibited anti-inflammatory properties and can fight several pathogens. They work by suppressing pro-inflammatory markers and cytokines. Apple Phlirodizin has been found to have antimicrobial activity, especially when consumed as food. 

In addition to mitigating inflammation through diet, Oridzin has the tendency to reduce nitric oxide production in stimulated cells. Its metabolites suppress the response in macrophages stimulated by LPS (lipopolysaccharides). This has been shown in various experimental models. 

Improves Your Liver Health

Studies have shown that Oridzin (polyphenolic compounds) has hepatoprotective activity and performs various functions. Its effects are marked by its impact on lipid metabolism, oxidative stress regulation, and the inhibition of hepatic inflammation and apoptosis. 

Oridzin potentially reduces the risk of liver damage by decreasing the contents of enzymes such as SGPT, ALP, etc. An experiment on mice has shown promise in relieving hepatic damage. This way, it alleviates hepatic steatosis and protects against drug-induced hepatic injury.


Fights Tumor And Cancerous Cells

Research suggests that Orid-zin may play a role in triggering cancer cell death. This presents the compound as a potential candidate for therapeutic interventions against cancer. It modulates cellular mechanisms responsible for cancer, including growth and proliferation.

Oridzin has been found to be an effective treatment for breast and colon cancer. Its derivatives have shown protective effects against various tumor cell lines and treat cancers. I’m not explaining the mechanisms here in detail, but this compound is a gem in this case. 

Beneficial In Lethal Cardiac Diseases

Orid-zin emerges as an efficient protector of the heart, showing potential in preventing coronary heart disease and diabetic cardiomyopathy. It has been associated with improvements in lipid metabolism, mitochondrial function, and the prevention of ventricular arrhythmias.

Phloridzin protects you against hyperglycemia-triggered injuries in diabetic cardiomyopathy. It reduces inflammation-related damage to cardiomyocytes and fibrosis. Studies have shown its effects in preventing hypertension by inhibiting SGLT2, mitigating the impact of hyperglycemia.

Positively Impact Your Bone Health 

Beyond its diverse range of activities, Orid-zin emerges as a potential supporter of bone health. Research suggests that it holds the capacity to improve bone conditions. Notably, it shows protective effects against bone loss in osteoporosis, particularly in relation to inflammation.

It has been linked to promoting osteoblastogenic bone formation. It does so by activating key signaling pathways involved in bone health. This way, it has a positive impact on bone density and strength. These findings mark the potential of Orid-zin as a paron to skeletal well-being.

Natural Sources of Orid-zin

Oridzin is obtained mostly from apple bark and leaves but is also present in its peel and pulp. An unpeeled apple is one of the richest sources of Phloridzin. According to studies, one kilogram (Kg) of peel contains 10 to 420 mg of Orid-zin, and the pulp has 4 to 20 mg of Oridzin.

Besides apples, phloridzin is present in various foods. These include:

  • Apples & Apricots
  • Mexican Oregano
  • Strawberries
  • European Plums
  • Pomegranates 

However, it has been detected in higher quantities in Mexican oregano and European plums but in lower concentrations in pomegranates and apricots. This diversity in its occurrence hints at the potential of Oridzin as a biomarker for identifying the consumption of specific foods.

Side Effects & Precautions

Exploring potential side effects and precautions associated with Orid-zin reveals the need for careful consideration. A study on mice shows dose-dependent toxicity, with the highest dose leading to 100% lethality. So, additional safety and regulatory toxicity studies are required.

Oral administration at the maximum dose can result in significant mortality. While lower doses appear safe, caution is still advised. Another compound, phlorizin, has negative effects on the muscles and skeleton in small amounts. That’s why ensure cautious use of the compound.

Adding Orid-zin To Your Diet

As you have read the benefits of Oridzin and know the primary sources, you might want to add it to your diet. If so, it’s quite simple to start consuming Orid-zin without causing any harmful effects. So, let’s elaborate on this further based on the two main sources: 

  • Natural Sources

The most straightforward method to incorporate Oridzin into your diet is by consuming apples and plums. You can get the compound from apple-based products like peels, juice, and cider. If you don’t want to consume higher amounts, start eating apricots regularly. 

  • Supplements

Oridzin drugs and supplements are available in various forms in developed countries. In this category, we have dapagliflozin and empagliflozin. You can also take Orid-zin in food from dried Mexican oregano. However, consult a healthcare expert before taking any supplement.


Oridzin, i.e., Phloridzin, is a phytochemical extracted from apple tree bark with a rich history dating back to 1835. This compound, belonging to the chalcone class, has many health benefits. It manages diabetes, fights infections, and shows promise in cancer treatment. 

So, Oridzin has potential health benefits and is a cure for lethal diseases, including cardiac ones. However, caution is advised due to potential side effects and dose-dependent toxicity. Further research into Orid-zin might bring more benefits to human health and well-being.

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